- Students in grades 4-12 who reside in or attend any public, parochial, private school, or home study in Bay, Genesee, Lapeer, Midland, Saginaw, Shiawassee, St. Clair, and Tuscola counties are encouraged to enter the Flint Regional Science Fair.
- Students from other Michigan counties may participate if not served by an ISEF affiliated fair.
- Students who hold a high school diploma or who are over 20 years old are not eligible.
- Projects will be divided into divisions as follows:
- Elementary Division Grades 4 and 5
- Junior Division Grades 6, 7, and 8
- Senior Division Grades 9–12
- Group Projects All Grades
Group projects (made by more than one pupil) will be judged against other group projects only.